2012 INIAstress Publications

Acosta G, Freidman DP, Grant KA, Hemby SE. Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. Front Psychiatry. 2012 Jan 3;2:72. doi: 10.3389/fpsyt.2011.00072. eCollection 2011. PubMed PMID: 22291662; PubMed Central PMCID: PMC3249828.

Andreux PA, Williams EG, Koutnikova H, Houtkooper RH, Champy MF, Henry H, Schoonjans K, Williams RW, Auwerx J. Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits. Cell. 2012 Aug 28. PMID: 22939713.

Becker HC. Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption. Alcohol Res. 2012;34(4):448-58. Review. PubMed PMID: 23584111; PubMed Central PMCID: PMC3860383.

Bhandari P, Hill JS, Farris SP, Costin B, Martin I, Chan CL, Alaimo JT, Bettinger JC, Davies AG, Miles MF, Grotewiel M. Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. Genes Brain Behav. 2012 Jun;11(4):387-97. doi: 10.1111/j.1601-183X.2012.00765.x. PMID: 22239914.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. PMID: 22037201; PMCID: PMC3263968.

Boughter JD Jr, Mulligan MK, St John SJ, Tokita K, Lu L, Heck DH, Williams RW. Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2. PLoS One. 2012;7(5):e38169. PMID: 22675444; PMCID: PMC3364982.

Brookshire BR, Jones SR. Chronic methylphenidate administration in mice produces depressive-like behaviors and altered responses to fluoxetine. Synapse. 2012 Sep;66(9):844-7. doi: 10.1002/syn.21569. PMID: 22588965; PMCID: PMC3625654.

Bruhn S, Barrenäs F, Mobini R, Andersson BA, Chavali S, Egan BS, Hovig E, Sandve GK, Langston MA, Rogers G, Wang H, Benson M. Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis. Allergy. 2012 Jan;67(1):33-40. doi: 10.1111/j.1398-9995.2011.02707.x. PMID: 21919915; PMCID: PMC3237963.

Brunschwig H, Levi L, Ben-David E, Williams RW, Yakir B, Shifman S. Fine-scale maps of recombination rates and hotspots in the mouse genome. Genetics. 2012 Jul;191(3):757-64. doi: 10.1534/genetics.112.141036. Epub 2012 May 4. PubMed PMID: 22562932; PubMed Central PMCID: PMC3389972.

Burnett EJ, Davenport AT, Grant KA, Friedman DP. The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Front Psychiatry. 2012;3:38. PMID:22557982, PMCID:PMC3337466.

Calipari ES, Huggins KN, Mathews TA, Jones SR. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochem Int. 2012 Jul 20. PMID: 22819794.

Costin BN, Wolen AR, Fitting S, Shelton KL, Miles MF. Role of adrenal glucocorticoid signaling in prefrontal cortex gene expression and acute behavioral responses to ethanol. Alcohol Clin Exp Res. 2012 Jun 4. doi: 10.1111/j.1530-0277.2012.01841.x. PMID: 22671426.

Eblen JD, Phillips CA, Rogers GL, Langston MA. The maximum clique enumeration problem: algorithms, applications, and implementations. BMC Bioinformatics. 2012 Jun 25;13 Suppl 10:S5. doi: 10.1186/1471-2105-13-S10-S5. PubMed PMID: 22759429; PubMed Central PMCID: PMC3382443.

Farris, SP and Miles MF. Ethanol modulation of gene networks: implications for alcoholism. Neurobiol Dis. 2012 Jan;45(1):115-21. PMID: 21536129; PMCID: PMC3158275.

Ferguson B, Hunter JE, Luty J, Street SL, Woodall A, Grant KA. Genetic load is associated with hypothalamic-pituitary-adrenal axis dysregulation in macaques. Genes Brain Behav. 2012 Sep 21. doi: 10.1111/j.1601-183X.2012.00856.x. PMID: 22998353; PMCID: PMC3595329.

Ford MM, McCracken AD, Davis NL, Ryabinin AE, Grant KA. Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation. Psychopharmacology (Berl). 2012 Jul 5. PMID: 22763667; PMCID: PMC3496813.

Hager R, Lu L, Rosen GD, Williams RW. Genetic architecture supports mosaic brain evolution and independent brain-body size regulation. Nat Commun. 2012;3:1079. doi: 10.1038/ncomms2086. PMID: 23011133.

Helms CM, McClintick MN, Grant KA. Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. Psychopharmacology (Berl). 2012 Apr 18. PMID: 22526537, PMCID: PMC3469782.

Helms CM, Messaoudi I, Jeng S, Freeman WM, Vrana KE, Grant KA. A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques. Alcohol Clin Exp Res. 2012 Jun;36(6):995-1003. doi: 10.1111/j.1530-0277.2011.01685.x. PMID: 22141444. PMCID:PMC3324628.

Helms CM, Rossi D, Grant KA. Neurosteroid effects on sensitivity to ethanol. Front Endocrinol (Lausanne). 2012;3:10. PMID:22654852; PMCID:PMC3356014.

Holmes A, Fitzgerald PJ, MacPherson KP, DeBrouse L, Colacicco G, Flynn SM, Masneuf S, Pleil KE, Li C, Marcinkiewcz CA, Kash TL, Gunduz-Cinar O, Camp M. Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding. Nat Neurosci. 2012 Oct;15(10):1359-61. doi: 10.1038/nn.3204. Epub 2012 Sep 2. PubMed PMID: 22941108; PubMed Central PMCID: PMC3471649.

Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012 Jun;46(4):371-6. PMID: 22445804.

Jay JJ, Eblen JD, Zhang Y, Benson M, Perkins AD, Saxton AM, Voy BH, Chesler EJ, Langston MA. A systematic comparison of genome-scale clustering algorithms. BMC Bioinformatics. 2012 Jun 25;13 Suppl 10:S7. doi: 10.1186/1471-2105-13-S10-S7. PubMed PMID: 22759431; PubMed Central PMCID: PMC3382433.

Jellen, LC, Unger, EL, Lu, L, Williams, RW, Rousseau, S, Wang, X, Earley, CJ, Allen, RP, Miles, MF, and Jones, BC. Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics. 2012 May;13(2):147-57. PMID: 22457016; PMCID: PMC3427775.

Karlsson RM, Adermark L, Molander A, Perreau-Lenz S, Singley E, Solomon M, Holmes A, Tanaka K, Lovinger DM, Spanagel R, Heilig M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology. 2012 Aug;63(2):181-9. doi: 10.1016/j.neuropharm.2012.01.027. PMID: 22342743; PMCID: PMC3372600.

Kash TL. (2012) The Role of Biogenic Amine Signaling in the Bed Nucleus of the Stria Terminals in Alcohol Abuse. Alcohol Jun;46(4):303-8. PMID: 22449787.

Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC, Chandler LJ. Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS One. 2012;7(5):e37541. doi: 10.1371/journal.pone.0037541. Epub 2012 May 30. PMID: 22666364

Logan RW, McCulley WD 3rd, Seggio JA, Rosenwasser AM.Effects of withdrawal from chronic intermittent ethanol vapor on the level and circadian periodicity of running-wheel activity in C57BL/6J and C3H/HeJ mice. Alcohol Clin Exp Res. 2012 Mar;36(3):467-76. doi: 10.1111/j.1530-0277.2011.01634.x. PMID: 22013893; PMCID: PMC3266959.

Lowery-Gionta EG, Navarro M, Li C, Pleil KE, Rinker JA, Cox BR, Sprow GM, Kash TL, Thiele TE. Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci. 2012 Mar 7;32(10):3405-13. doi: 10.1523/JNEUROSCI.6256-11.2012. PubMed PMID: 22399763; PubMed Central PMCID: PMC3307528.

Melendez RI, McGinty JF, Kalivas PW, Becker HC. Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice. Addict Biol. 2012 Mar;17(2):351-64. doi: 10.1111/j.1369-1600.2011.00357.x. Epub 2011 Aug 4. PMID: 21812870.

McKnite AM, Perez-Munoz ME, Lu L, Williams EG, Brewer S, Andreux PA, Bastiaansen JW, Wang X, Kachman SD, Auwerx J, Williams RW, Benson AK, Peterson DA, Ciobanu DC. Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One. 2012;7(6):e39191. PMID: 22723961; PMCID: PMC3377628.

Mozhui K, Lu L, Armstrong WE, Williams RW. Sex-specific modulation of gene expression networks in murine hypothalamus. Front Neurosci. 2012;6:63. PMID: 22593731; PMCID: PMC3350311.

Mulholland PJ. K(Ca)2 channels: novel therapeutic targets for treating alcohol withdrawal and escalation of alcohol consumption. Alcohol. 2012 Jun;46(4):309-15. doi: 10.1016/j.alcohol.2011.11.002. Epub 2012 Mar 30. Review. PMID: 22464787

Mulligan MK, Wang X, Adler AL, Mozhui K, Lu L, Williams RW. Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation. PLoS One. 2012;7(4):e34586. PMID: 22506031; PMCID: PMC3323555.

Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, Heßman M, Alberts R, Williams RW, Schughart K. Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. BMC Genomics. 2012 Aug 20;13:411. doi: 10.1186/1471-2164-13-411. PubMed PMID: 22905720; PubMed Central PMCID: PMC3479429.

O'Brien MA, Costin BN, Miles MF. Using genome-wide expression profiling to define gene networks relevant to the study of complex traits: from RNA integrity to network topology. Int Rev Neurobiol. 2012;104:91-133. doi:10.1016/B978-0-12-398323-7.00005-7. Review. PubMed PMID: 23195313; PubMed Central PMCID: PMC4104526.

Parker CC, Cheng R, Sokoloff G, Palmer AA. Genome-wide association for methamphetamine sensitivity in an advanced intercross mouse line. Genes Brain Behav. 2012 Feb;11(1):52-61. doi: 10.1111/j.1601-183X.2011.00747.x. PMID: 22032291; PMCID: PMC3368015.

Pleil KE, Lopez A, McCall N, Jijon AM, Bravo JP, Kash TL. Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology. 2012 Mar;62(4):1777-86. doi: 10.1016/j.neuropharm.2011.12.002. Epub 2011 Dec 9. PubMed PMID: 22182779; PubMed Central PMCID: PMC3269561.

Prendergast MA, Mulholland PJ. Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury. Addict Biol. 2012 Mar;17(2):209-23. doi: 10.1111/j.1369-1600.2011.00375.x. Epub 2011 Oct 4. Review. PMID: 21967628.

Reinius B, Johansson MJ, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Williams RW, Jazin E. Abundance of female-biased and paucity of male-biased somatically expressed genes on the X-chromosome. BMC Genomics. 2012 Nov 10;13:607. PMID: 23140559;PMCID: PMC3534601.

Rohlfing T, Kroenke CD, Sullivan EV, Dubach MR, Bowden DM, Grant KA, Pefferbaum A. The INIA19 template and NeuroMaps atlas for primate brain image parcellation and spatial normalization. Front Neuroinform. 2012;6:27. PMID: 23230398; PMCID: PMC3515865.

Sparrow AM, Lowery-Gionta EG, Pleil KE, Li C, Sprow GM, Cox BR, Rinker JA, Jijon AM, Peňa J, Navarro M, Kash TL, Thiele TE. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology. 2012 May;37(6):1409-21. doi: 10.1038/npp.2011.327. Epub 2012 Jan 4. PubMed PMID: 22218088; PubMed Central PMCID: PMC3327846.

Talishinsky A, Rosen GD. Systems genetics of the lateral septal nucleus in mouse: heritability, genetic control, and covariation with behavioral and morphological traits. PLoS One. 2012;7(8):e44236. doi: 10.1371/journal.pone.0044236. PMID: 22952935; PMCID: PMC3432065.

Wang X, Mozhui K, Li Z, Mulligan MK, Ingels JF, Zhou X, Hori RT, Chen H, Cook MN, Williams RW, Lu L. A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Transl Psychiatry. 2012 Jan 31;2:e73. doi: 10.1038/tp.2011.71. PMID: 22832735; PMCID: PMC3309544.

Williams RW (2012) Genetic and genomic web resources for research on alcohol use and abuse. Alcohol Research, Current Reviews 34:378–380.

Williams RW, Mulligan MK. Genetic and molecular network analysis of behavior. Int Rev Neurobiol. 2012;104:135-57. doi: 10.1016/B978-0-12-398323-7.00006-9. PMID: 23195314.

Williams RW, Norohna A (2012) A watershed year for an update on the genetics of alcoholism. Alcohol Research, Current Reviews 34:263.

Wills TA, Klug JR, Silberman Y, Baucum AJ, Weitlauf C, Colbran RJ, Delpire E, Winder DG. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E278-87. PMID: 22219357; PMCID: PMC3277158.

Wolen AR, Phillips CA, Langston MA, Putman AH, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF. Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. PLoS One. 2012;7(4):e33575. Epub 2012 Apr 12. PMID: 22511924; PMCID: PMC3325236.

Yang H, Spence JS, Devous MD Sr, Briggs RW, Goyal A, Xiao H, Yadav H, Adinoff B. Striatal-limbic activation is associated with intensity of anticipatory anxiety. Psychiatry Res. 2012 Nov 30;204(2-3):123-31. doi: 10.1016/j.pscychresns.2012.10.001. Epub 2012 Nov 6. PubMed PMID: 23137803; PubMed Central PMCID: PMC3562596.

Yorgason JT, Espana RA, Konstantopoulos JK, Weiner JL and Jones SR. Enduring increases in anxiety-like behavior and nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013 Mar;37(6):1022-31. PMID: 23294165

Zhao Z, Guo AY, van den Oord EJ, Aliev F, Jia P, Edenberg HJ, Riley BP, Dick DM, Bettinger JC, Davies AG, Grotewiel MS, Schuckit MA, Agrawal A, Kramer J, Nurnberger JI Jr, Kendler KS, Webb BT, Miles MF. Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. BMC Genomics. 2012;13 Suppl 8:S16. doi: 10.1186/1471-2164-13-S8-S16. Epub 2012 Dec 17. PubMed PMID: 23282140; PubMed Central PMCID: PMC3535715.

Ziebarth JD, Cook MN, Wang X, Williams RW, Lu L, Cui Y. Treatment- and population-dependent activity patterns of behavioral and expression QTLs. PLoS One. 2012;7(2):e31805. Epub 2012 Feb 16. PMID: 22359631; PMCID: PMC3281015.